Obama surveys Sandy disaster in NJ

Some areas along the New Jersey coastline will be without power for another week and the water may be turned off as well. NBC's Ron Allen reports.

Doug Mills / AFP - Getty Images

President Barack Obama flies over Seaside Heights, N.J., on Wednesday.

By Miguel Llanos, NBC News

President Barack Obama surveyed New Jersey's battered coastline on Wednesday, saying the federal government was "going to be here for the long haul,"?as the state and 15 others dealt with cleanup and power outages two days after Superstorm Sandy tore through.

After a helicopter tour, Obama visited residents in hard-hit Brigantine, where he made his promise of long-term support.

He was shown around by New Jersey Gov. Chris Christie, a Republican and vocal backer of presidential challenger Mitt Romney who nevertheless has praised Obama and the federal response to the storm.

"We're going to work together to make sure we get ourselves through this crisis," Christie said after Obama's remarks.

Christie earlier said he would ask the president to task the Army Corps of Engineers with how "to rebuild the beach to protect these towns."

But, he added, "it won't be the same because some of the iconic things are washed into the ocean."

Christie on Wednesday ordered that Halloween trick-or-treating be moved to Monday due to unsafe conditions.?Aerial footage of the coastline Wednesday morning showed mile after mile of destruction: a neighborhood on fire, others swamped by sand and evacuations still happening in places with high water.

NBC's Lester Holt walks through a destroyed restaurant in Point Pleasant Beach, N.J., which has been completely filled with sand by Sandy.

Recovery operations on Wednesday got a boost from the Navy, which ordered three helicopter carrier ships to the New Jersey and New York coasts, officials told NBC News.

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The USS Wasp, USS Carter Hall, and USS Mesa Verde will provide landing platforms for Coast Guard, National Guard and civilian agency helicopters if needed, the officials said, adding that the Atlantic Fleet command made the decision in the name of "prudent planning."

Wall Street reopened Wednesday,?as did some airports, but 5.7 million?homes and businesses -- two thirds in New Jersey and New York -- still were without power Wednesday afternoon.?

Aerial footage reveals devastation from New York City to North Carolina's Outer Banks.

Two days after landfall, Sandy was still impacting areas from the Atlantic coast to as far inland as Chicago:

• Some 500 patients at New York City's Bellevue Hospital were being evacuated Wednesday after lab equipment was damaged by floodwater.
• Three of seven flooded East River tunnels in New York City were cleared of water on Wednesday, and some subway service was set to resume Thursday. Full bus service was restored, as was some train service.
• New York City schools will be closed the rest of the week, Mayor Michael Bloomberg said.
• 90 percent of Long Island was without power and it could take up to 10 days to restore all service, Rep. Steve Israel, D-N.Y., told MSNBC.
• Sewage was backing up into homes near a flooded sewage plant in Long Island's Nassau County. An official feared it could spread to thousands of homes.?
• The U.N. Security Council had to relocate because of water damage to parts of U.N. headquarters in Manhattan.?
• Fires that destroyed more than a dozen homes in a New Jersey shore town rekindled overnight due to natural gas leaks,?NBCNewYork.com reported. Other communities up and down the coast also saw fires destroy homes.
• National Guard troops were evacuating flooded neighborhoods in Hoboken, N.J., NBCNewYork.com reported.?"About 20,000 people still remain in their homes, and we're trying to put together an evacuation plan, get the equipment here," Mayor Dawn Zimmer told MSNBC Tuesday night.?
• New Jersey's barrier islands were literally reshaped by the surge of water, NBC's Al Roker reported.
• More than three feet of snow had fallen in parts of West Virginia, where 225,000 homes and businesses were without power Wednesday morning. Red House, Md., saw 30 inches of snow.
• In Chicago, forecasters warned that high waves and flooding are possible on the Lake Michigan shore on Wednesday.?Sandy caused waves up to two stories high on the Great Lakes Tuesday, forcing cargo ships -- some longer than three football fields -- to seek shelter.?"We don't stop for thunderstorms and flurries," said Glen Nekvasil, spokesman for lake cargo association. "But this was just too much."
• In New Haven, Conn., Sandy blew down a tree that uprooted human remains and what appeared to be a time capsule.?

Helicopter aerials show an out-of-control blaze burning in Mantoloking, N.J., a community left devastated by Superstorm Sandy. TODAY's Natalie Morales reports.

Interactive storm tracker
Sandy leaves trail of destruction, disbelief

Sandy has claimed at least 47 lives in the U.S., after killing at least?71 in the Caribbean.

In New Jersey, aerial footage Wednesday showed fires raging among storm-damaged homes and sand pushed inland, with TODAY's Natalie Morales reporting from the air that she counted some 25 separate points of flame.

Boats that Morales said had been "tossed as if toys" could be seen piled up next to wrecked houses in the area.?

The National Guard has arrived in Hoboken, N.J., to give much-needed help to people trapped in their homes by flooding. Many of the city's streets are still under multiple feet of water. NBC's Natalie Morales takes an aerial view.

BreakingNews.com's coverage of Sandy

In Hoboken, across from Manhattan, live wires dangled in floodwaters that were rapidly mixing with sewage.

The lower half of Manhattan remained without power after a transformer explosion at a Con Edison substation Monday night.

Superstorm Sandy made landfall Monday evening on a destructive and deadly path across the Northeast.

Two of the area's three major airports -- ?Kennedy in New York and Newark Liberty -- reopened with limited service on Wednesday.?New York's LaGuardia Airport was flooded and remained closed. Nearly 19,000 flights have been canceled since Sunday.

Sunday?s New York Marathon is still on, but?flying in runners from out of town will be tricky. The National Basketball Association canceled the season-opening game between the New York Knicks and the Brooklyn Nets on Thursday, because of damage around the Barclays Center in Brooklyn.

NBC Pentagon correspondent Jim Miklaszewski as well as Reuters and The Associated Press contributed to this report.

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Source: http://usnews.nbcnews.com/_news/2012/10/31/14830067-obama-surveying-nj-disaster-navy-sends-carriers-to-help-with-sandy-recovery?lite

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Superstorm Sandy Aftermath: Film, TV & Broadway Slowly Star To ...

Hoboken, N.J.

Members of the National Guard stand ready with large trucks used to pluck people from high water in Hoboken, N.J. on Oct. 31, 2012 in the wake of superstorm Sandy. Parts of the city are still covered in standing water, trapping some residents in their homes. (Craig Ruttle, AP)

Staten Island, N.Y.

Members of the Fire Department of New York (FDNY) search for stranded residents as they navigate through flood waters on Hylan Boulevard in the Staten Island borough of New York, U.S., on Tuesday, Oct. 30, 2012. New York City officials spent the day grappling with the damage from Sandy, the Atlantic superstorm that killed 10 people, sparked a fire that destroyed 111 homes in Queens, flooded tunnels of the biggest U.S. transit system and left more than 750,000 customers without power.

Edison, N.J.

People wait in line to fill containers with fuel at a Shell gas station Oct. 30, 2012 in Edison, New Jersey. Hurricane Sandy which hit New York and New Jersey left much of Bergen County flooded and without power.

East Village, New York City

People gather inside Dorian Gray Tap and Grill during a power outage following Hurricane Sandy, Oct. 30, 2012 in the East Village neighborhood of New York City. The storm has claimed at least 40 lives in the United States, and has caused massive flooding accross much of the Atlantic seaboard leaving millions of people without power. US President Barack Obama has declared the situation a 'major disaster' for large areas of the US East Coast including New York City.

New York City

Clouds hang over the darkened lower Manhattan skyline at night in New York, U.S., on Tuesday, Oct. 30, 2012. New York City officials spent the day grappling with the damage from Sandy, the Atlantic superstorm that killed 10 people, sparked a fire that destroyed 111 homes in Queens, flooded tunnels of the biggest U.S. transit system and left more than 750,000 customers without power.

Hoboken, N.J.

The twisted remains of a Hudson River marina are seen across from New York City as a result of superstorm Sandy on Tuesday, Oct. 30, 2012 in Hoboken, NJ.

Hoboken, N.J.

A resident walks through flood water and past a stalled ambulance in the aftermath of superstorm Sandy on Tuesday, Oct. 30, 2012 in Hoboken, NJ.

Hoboken, NJ.

Cars sit in flood water as a result of superstorm Sandy on Tuesday, Oct. 30, 2012 in Hoboken, NJ.

Hoboken, N.J.

A yacht washes up on the waterfront of the Hudson River as a result of superstorm Sandy on Tuesday, Oct. 30, 2012 in Hoboken, NJ.

Chesapeake Beach, MD

A downed tree and power lines block Rt. 261 in Calvert County just south of Chesapeake Beach on Tuesday morning in the wake of Hurricane Sandy, in Chesapeake Beach, MD, on Oct. 30, 2012.

Reagan National Airport

A lone arriving passenger walks onto the Reagan National Airport Metro platform just after Metro reopened the system this after noon after Hurricane Sandy in Arlington VA, Oct. 30, 2012.

People in New York's Tribeca neighborhood, without power because of superstorm Sandy, wait for a chance to charge their mobile phones on an available generator setup on a sidewalk, Tuesday, Oct. 30, 2012. Sandy, the storm that made landfall Monday, caused multiple fatalities, halted mass transit and cut power to more than 6 million homes and businesses. (AP Photo/Richard Drew)

People take photos at water filling the Bowling Green subway station in Battery Park in New York on October 30, 2012 as New Yorkers cope with the aftermath of Hurricane Sandy. The storm left large parts of New York City without power and transportation. TIMOTHY A. CLARY/AFP/Getty Images

North Carolina 12 is buckled from pounding surf leading into Mirlo Beach in Rodanthe, N.C. on Tuesday, Oct. 30, 2012. People on North Carolina's Outer Banks are facing some flooding and damage from Hurricane Sandy, but emergency management officials say it could have been worse. North Carolina Transportation Department spokeswoman Greer Beaty said the highway was closed Tuesday until crews inspect the road. (AP Photo/The Virginian-Pilot, Steve Earley)

Foundations and pilings are all that remain of brick buildings and a boardwalk in Atlantic City, N.J., Tuesday, Oct. 30, 2012, after they were destroyed when a powerful storm that started out as Hurricane Sandy made landfall on the East Coast on Monday night. (AP Photo/Seth Wenig)

FARMINGDALE, NY - OCTOBER 30: Timothy Henggeler, Logistics Specialist with FEMA speaks with New York guard members at Republic Airport in the aftermath of Hurricane Sandy on October 30, 2012 in Farmingdale, New York. The storm has claimed at least a few dozen lives in the United States, and has caused massive flooding across much of the Atlantic seaboard. U.S. President Barack Obama has declared the situation a 'major disaster' for large areas of the U.S. east coast, including New York City. (Photo by Bruce Bennett/Getty Images)

Breezy Point, N.Y.

A firefighter works to contain a fire that destroyed over 50 homes during Hurricane Sandy on Oct. 30, 2012 in the Breezy Point neighborhood of the Queens borough of New York. At least 33 people were reported killed in the United States by Sandy as millions of people in the eastern United States have awoken to widespread power outages, flooded homes and downed trees. New York City was hit especially hard with wide spread power outages and significant flooding in parts of the city. (Spencer Platt, Getty Images)

Pleasure boats pile up 30 yards or more from the water?s edge in the wake of Hurricane Sandy, Tuesday, Oct. 30, 2012, in the Cliffwood Beach section of Aberdeen, N.J. The storm's high winds and the high astronomical tide paired up to rip the boats away from their dock and deposit them on shore. (AP Photo/Peter Hermann, III)

A parking lot full of yellow cabs is flooded as a result of superstorm Sandy on Tuesday, Oct. 30, 2012 in Hoboken, NJ. (AP Photo/Charles Sykes)

East Coast Begins To Clean Up And Assess Damage From Hurricane Sandy

OCEAN CITY, NJ - OCTOBER 30: Residents survey the damage after Hurricane Sandy on October 30, 2012 in Ocean City, New Jersey. Sandy made landfall last night on the New Jersey coastline bringing heavy winds and record floodwaters. At least two dozen people were reported killed in the United States as millions of people in the eastern United States are experiencing widespread power outages, flooded homes and downed trees. (Photo by Mark Wilson/Getty Images)

Jason Locke sweeps water and mud from his parents' home in Westport, Mass., Tuesday, Oct. 30, 2012. Many homeowners who suffered losses because of flooding from Hurricane Sandy are likely to find themselves out of luck. Standard homeowners policies don't cover flooding damage, and the vast majority of homeowners don't have flood insurance.Yet it's likely that many Northeasterners will purchase it in coming months, hoping they'll be covered the next time around, at a cost averaging around $600 a year. (AP Photo/The Standard Times, Peter Pereira)

The tailend of a SUV is perched on top of a postal mailbox in the aftermath of floods from Hurricane Sandy on Tuesday, Oct. 30, 2012, in Coney Island, N.Y. Sandy, the storm that made landfall Monday, caused multiple fatalities, halted mass transit and cut power to more than 6 million homes and businesses. (AP Photo/Bebeto Matthews)

HUNTINGTON, NY - OCTOBER 30: Power lines rest at a 45 degree angle on Clinton Avenue in the aftermath of Hurricane Sandy on October 30, 2012 in Huntington, New York. The storm has claimed at least a few dozen lives in the United States, and has caused massive flooding across much of the Atlantic seaboard. U.S. President Barack Obama has declared the situation a 'major disaster' for large areas of the U.S. east coast, including New York City. (Photo by Bruce Bennett/Getty Images)

A flood damaged vehicle is surrounded by debris in Mirlo Beach in Rodanthe, N.C. on Tuesday, Oct. 30, 2012. People on North Carolina's Outer Banks are facing some flooding and damage from Hurricane Sandy, but emergency management officials say it could have been worse. (AP Photo/The Virginian-Pilot, Steve Earley)

A police officer watch as a passerby look into a store through a damaged security grate, in the aftermath of Hurricane Sandy on Tuesday, Oct. 30, 2012, on Mermaid Avenue in Coney Island, N.Y. Sandy, the storm that made landfall Monday, caused multiple fatalities, halted mass transit and cut power to more than 6 million homes and businesses.(AP Photo/Bebeto Matthews)

HUNTINGTON STATION, NY - OCTOBER 30: A sporting goods and camping store displays it's message to residents in the aftermath of Hurricane Sandy on October 30, 2012 in Huntington Station, New York. The storm has claimed at least a few dozen lives in the United States, and has caused massive flooding across much of the Atlantic seaboard. U.S. President Barack Obama has declared the situation a 'major disaster' for large areas of the U.S. east coast, including New York City. (Photo by Bruce Bennett/Getty Images)

Nicholas Rodriguez looks over a section of the destroyed boardwalk in Atlantic City, N.J., Tuesday, Oct. 30, 2012, not far from where a powerful storm that started out as Hurricane Sandy made landfall the night before. Millions of people from Maine to the Carolinas awoke Tuesday without electricity, but the full extent of the damage in New Jersey, where the storm roared ashore Monday night with hurricane force, was unclear. (AP Photo/Seth Wenig)

People walk on North Carolina 12 away from the buckling of the highway, pounded by surf, leading into Mirlo Beach in Rodanthe, N.C. on Tuesday, Oct. 30, 2012. People on North Carolina's Outer Banks are facing some flooding and damage from Hurricane Sandy, but emergency management officials say it could have been worse. North Carolina Transportation Department spokeswoman Greer Beaty said the highway was closed Tuesday until crews inspect the road. (AP Photo/The Virginian-Pilot, Steve Earley)

A huge tree split apart and fell over the front yard and fence of a home on Carpenter Avenue in the aftermath of Hurricane Sandy on Tuesday, Oct., 30, 2012, in Sea Cliff, N.Y. (AP Photo/Kathy Kmonicek)

Little Ferry, N.J.

Olivia Loesner, 16, hugs her uncle, Little Ferry Deputy Fire Chief John Ruff, after she was brought from her flooded home in a boat in Little Ferry, N.J., Tuesday, Oct. 30, 2012, in the wake of superstorm Sandy. At right carrying pets, is her mother, Janice Loesner. (Craig Ruttle, AP)

Ocean City, M.D.

A National Guard humvee travels through high water to check the area after the effects of Hurricane Sandy Tuesday, Oct. 30, 2012, in Ocean City, Md. Sandy, the storm that made landfall Monday, caused multiple fatalities, halted mass transit and cut power to more than 6 million homes and businesses. (Alex Brandon, AP)

Cleveland, Ohio

Waves pound a lighthouse on the shores of Lake Erie Tuesday, Oct. 30, 2012, near Cleveland. High winds spinning off the edge of superstorm Sandy took a vicious swipe at northeast Ohio early Tuesday, uprooting trees, cutting power to hundreds of thousands, closing schools and flooding parts of major commuter arteries that run along Lake Erie. (Tony Dejak, AP)

OCEAN CITY, NJ - OCTOBER 30: Streets remain flooded after Hurricane Sandy on October 30, 2012 in Ocean City, New Jersey. Sandy made landfall last night on the New Jersey coastline bringing heavy winds and record floodwaters. At least two dozen people were reported killed in the United States as millions of people in the eastern United States are experiencing widespread power outages, flooded homes and downed trees. (Photo by Mark Wilson/Getty Images)

A log rests on a vehicle damaged by superstorm Sandy at Breezy Point in the New York City borough of Queens, Tuesday, Oct. 30, 2012, in New York. The fire destroyed between 80 and 100 houses Monday night in the flooded neighborhood. (AP Photo/Frank Franklin II)

OCEAN CITY, MD - OCTOBER 30: People participate in metal detecting at the beach after Hurricane Sandy hit the region October 30, 2012 in Ocean City, Maryland. The storm has claimed at least 33 lives in the United States, and has caused massive flooding across much of the Atlantic seaboard. U.S. President Barack Obama has declared the situation a 'major disaster' for large areas of the U.S. east coast, including New York City, with widespread power outages and significant flooding in parts of the city. (Photo by Alex Wong/Getty Images)

FARMINGDALE, NY - OCTOBER 30: (L-R) Mike Cassidy and Warren Connolly work to clear trees from Secatouge Avenue in the aftermath of Hurricane Sandy on October 30, 2012 in Farmingdale, New York. The storm has claimed at least a few dozen lives in the United States, and has caused massive flooding across much of the Atlantic seaboard. U.S. President Barack Obama has declared the situation a 'major disaster' for large areas of the U.S. east coast, including New York City. (Photo by Bruce Bennett/Getty Images)

East Coast Begins To Clean Up And Assess Damage From Hurricane Sandy

PLAINVIEW, NY - OCTOBER 30: Motorists wind their way up Manetto Hill Road in the aftermath of Hurricane Sandy on October 30, 2012 in Plainview, New York. The storm has claimed at least a few dozen lives in the United States, and has caused massive flooding across much of the Atlantic seaboard. U.S. President Barack Obama has declared the situation a 'major disaster' for large areas of the U.S. east coast, including New York City. (Photo by Bruce Bennett/Getty Images)

East Coast Begins To Clean Up And Assess Damage From Hurricane Sandy

OCEAN CITY, NJ - OCTOBER 30: A picnic table sits on a sand covered road after Hurricane Sandy on October 30, 2012 in Ocean City, New Jersey. Sandy made landfall last night on the New Jersey coastline bringing heavy winds and record floodwaters. At least two dozen people were reported killed in the United States as millions of people in the eastern United States are experiencing widespread power outages, flooded homes and downed trees. (Photo by Mark Wilson/Getty Images)

Two women shop for groceries by flashlight in the Tribeca neighborhood of New York, Tuesday, Oct. 30, 2012. ConEd cut power Moday to some neighborhoods served by underground lines as the advancing storm surge from Hurricane Sandy threatened to flood substations. Floodwaters later led to explosions that disabled a substation in Lower Manhattan, cutting power tens of thousands of customers south of 39th Street. (AP Photo/Richard Drew)

Ground Zero Floods

Sea water floods the Ground?Zero construction site, Monday, Oct. 29, 2012, in New York. Sandy continued on its path Monday, as the storm forced the shutdown of mass transit, schools and financial markets, sending coastal residents fleeing, and threatening a dangerous mix of high winds and soaking rain.? (AP Photo/ John Minchillo)

LONG BEACH, NY - OCTOBER 30: Residents walk on a street covered in beach sand due to flooding from Hurricane Sandy on October 30, 2012 in Long Beach, New York. The storm has claimed at least 33 lives in the United States, and has caused massive flooding across much of the Atlantic seaboard. U.S. President Barack Obama has declared the situation a 'major disaster' for large areas of the U.S. east coast, including New York City, with widespread power outages and significant flooding in parts of the city. (Photo by Mike Stobe/Getty Images)

A man looks down at water filling the Bowling Green subway station in Battery Park in New York on October 30, 2012 as New Yorkers cope with the aftermath of Hurricane Sandy. The storm left large parts of New York City without power and transportation. TIMOTHY A. CLARY/AFP/Getty Images

LONG BEACH, NY - OCTOBER 30: A section of an old boardwalk is seen destroyed by flooding from Hurricane Sandy on October 30, 2012 in Long Beach, New York. The storm has claimed at least 33 lives in the United States, and has caused massive flooding across much of the Atlantic seaboard. U.S. President Barack Obama has declared the situation a 'major disaster' for large areas of the U.S. east coast, including New York City, with widespread power outages and significant flooding in parts of the city. (Photo by Mike Stobe/Getty Images)

Ocean City, M.D.

Michael Brown, left, and Enos Jones, with Ocean City, fill a truck with debris as they clean the boardwalk after the effects of Hurricane Sandy Tuesday, Oct. 30, 2012, in Ocean City, Md. Sandy, the storm that made landfall Monday, caused multiple fatalities, halted mass transit and cut power to more than 6 million homes and businesses.(Alex Brandon, AP)

A man cleans up the remains of his food store damaged by Hurricane Sandy, in New York's South Street Seaport, Tuesday, Oct. 30, 2012. New York City awakened Tuesday to a flooded subway system, shuttered financial markets and hundreds of thousands of people without power a day after a wall of seawater and high winds slammed into the city, destroying buildings and flooding tunnels. (AP Photo/Richard Drew)

Members of the Saint Joseph's University crew team pull a damaged boat from the Schuylkill river in the wake of superstorm Sandy, Tuesday, Oct. 30, 2012, in Philadelphia. A one-two punch of rain and high wind from a monster hybrid storm that started out as a hurricane battered Pennsylvania, leaving more than a million customers without power as officials began assessing the damage Tuesday. (AP Photo/Matt Slocum)

Workers clear debris outside the Consolidated Edison power sub-station on 14th Street, Tuesday, Oct. 30, 2012, in New York. Hurricane Sandy marched slowly inland, leaving millions without power or mass transit, with huge swatches of the nation's largest city unusually vacant and dark. New York was among the hardest hit, with its financial heart in Lower Manhattan shuttered for a second day and seawater cascading into the still-gaping construction pit at the World Trade Center (AP Photo/ John Minchillo)

Belington, W.Va.

An ambulance is stuck in over a foot of snow off of Highway 33 West, near Belington, W.Va. on Tuesday, Oct. 30, 2012, in Belington, W.Va. Superstorm Sandy buried parts of West Virginia under more than a foot of snow on Tuesday, cutting power to at least 264,000 customers and closing dozens of roads. At least one death was reported. The storm not only hit higher elevations hard as predicted, communities in lower elevations got much more than the dusting of snow forecasters had first thought from a dangerous system that also brought significant rainfall, high wind gusts and small-stream flooding. (Robert Ray, AP)

North Carolina 12 is buckled from pounding surf leading into Mirlo Beach in Rodanthe, N.C. on Tuesday, Oct. 30, 2012. People on North Carolina's Outer Banks are facing some flooding and damage from Hurricane Sandy, but emergency management officials say it could have been worse. North Carolina Transportation Department spokeswoman Greer Beaty said the highway was closed Tuesday until crews inspect the road. (AP Photo/The Virginian-Pilot, Steve Earley)

Carol Mason mops her flooded floor with towels after returning to her home in Atlantic City, N.J., Tuesday, Oct. 30, 2012. Many homeowners who suffered losses because of flooding from Hurricane Sandy are likely to find themselves out of luck. Standard homeowners policies don't cover flooding damage, and the vast majority of homeowners don't have flood insurance. Yet it's likely that many Northeasterners will purchase it in coming months, hoping they'll be covered the next time around, at a cost averaging around $600 a year. (AP Photo/Seth Wenig)

Source: http://www.huffingtonpost.com/2012/10/31/superstorm-sandy-aftermath-nyc-entrtainmen_n_2048791.html

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Again... a new one

Hey there!
My name is Syshil and i'm an 19 years old girl born in the Netherlands. I may not be the best writer in english, but i want to give it a try you know... i'm just addicted to roleplaying, and have always been roleplaying with some friends of mine... but they kinda "stopped" some time ago, and left me and my imagionation bleeding and alone.
In real life i'm a student, trying hard to become a VET one day. So, i guess you understand that next to writing, animals are like... my obsession. Also i love to create and think up my own clothes, based on games like Assassins creed, Animes, Movies, etc. Yup, a whole package of imagionation!

Now, let's talk a little bit more about Roleplaying. I have started roleplaying in english on the age of... 10 i think. So, that's 9 years of experience. I know sometimes my english grammer goes totally wrong, and i appreciate it when people notice that and tell me what exactly i am doing wrong. I want to become a better writer in english of course.
My roleplay interests are mainly Magic and Fantasy... I like dramatic roleplays.. with suspence... and everytime a player goes offline... there is a huge cliffhanger! I love it... i really do... and i have this great story in my mind for a long time already after reading a book. I really, really want to roleplay and i only roleplay in the "I-form" ("I walked down the road"... instead of "Darian walked down the road"... it makes me feel more connected with my characters) and obviously like it when the people i roleplay with have that same writing style. It makes things more interesting i think.

I still do not know sure how Valucre actually works... but i really want to start this roleplay i have in mind... and create my characters that only live in my head... If there's anybody around who feels like..... helping me every now and then... i would love it!

Well, enough about this boring story about ME.... should we just get started roleplaying now? I made this roleplay called "The Guild", and i really want to get started. Some people send me PM's, but i still can't reply as i didn't unlock the PM-function yet ;).
x Syshil

Source: http://feedproxy.google.com/~r/RolePlayGateway/~3/dvR1DFbiGds/viewtopic.php

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CNN takes down 'hormones' voting story after backlash

Thinkstock.comA CNN.com story headlined "Do hormones drive women's votes?" sparked a social media backlash that lasted for seven hours Wednesday before the network removed the post late that night.

The story, posted in the website's medical and health section Wednesday afternoon, began, "There's something that may raise the chances for both presidential candidates that's totally out of their control: women's ovulation cycles."

The story cited a new study to be published in "Psychological Science"?by Kristina Durante, an assistant professor in the department of marketing at the University of Texas San Antonio and the study's main author. Durante's online surveys of several-hundred women led her to conclude that, when they are ovulating, single women espouse more liberal beliefs, while married or committed women gravitate towards more conservative views.

(The same journal published a study in October concluding that the more muscular a man is, the more likely he is to support government policies that serve his self interest, such as low taxes for the rich if he is wealthy.)

CNN said Durante hypothesized that single women "feel sexier" when ovulating and thus "lean more toward liberal attitudes on abortion and marriage equality." Married women, trying to resist their "sexy" feelings, do the opposite.

Durante wrote in an email to Yahoo News that there were some "misunderstandings" of her research in the CNN piece, but did not elaborate.

A barrage of women took to Twitter to mock the premise that women vote with their hormones and wondered why a similar story was not written about the biochemical changes of men and how they affect their votes.

"When I ovulate I'm all 'DEFICIT SPENDING SPURS THE ECONOMY' but when I'm not I want to privatize Social Security," joked one?of the thousands of people to weigh in on the story there.

The author of the CNN post, Elizabeth Landeau, defended the story, writing on Twitter that it was a peer-reviewed study and that she included skepticism from political scientists.?Landeau quoted Paul Kellstedt, for instance, associate professor of political science at Texas A&M University, who said that the study leaves out that men's behavior is also affected by biochemical changes.?Another political scientist, Susan Carroll of Rutgers, was quoted saying the difference between voting preferences of married and single women is better explained by the difference in their economic statuses and other non-hormonal factors.

When CNN took down the post it appended a note that read, "Some elements of the story did not meet the editorial standards of CNN," but did not specify which elements were not up to snuff. A spokesman there hasn't yet responded to Yahoo News's request for comment.

Source: http://news.yahoo.com/blogs/ticket/cnn-takes-down-hormones-drive-women-votes-story-152048023.html

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Legal Scholars: Thumbs Down on Patent and Copyright

There has long been skepticism about state-granted ?intellectual? monopoly privileges among economists, and even this is growing in recent decades. See, e.g., my posts?The Overwhelming Empirical Case?Against?Patent and Copyright,?The Four Historical Phases of IP Abolitionism, and?The Origins of Libertarian IP Abolitionism. As a sampler (more detail in the first link above):

Fritz Machlup, 1958:

No economist, on the basis of present knowledge, could possibly state with certainty that the patent system, as it now operates, confers a net benefit or a net loss upon society. The best he can do is to state assumptions and make guesses about the extent to which reality corresponds to these assumptions. ? If we did not have a patent system, it would be irresponsible, on the basis of our present knowledge of its economic consequences, to recommend instituting one.

Fran?ois L?v?que and Yann M?ni?re (Ecole des mines de Paris, 2004):

The abolition or preservation of intellectual property protection is ? not just a purely theoretical question. To decide on it from an economic viewpoint, we must be able to assess all the consequences of protection and determine whether the total favorable effects for society outweigh the total negative effects. Unfortunately, this exercise [an economic analysis of the cost and benefits of intellectual property] is no more within our reach today than it was in Machlup?s day [1950s].

Boston University Law School Professors (and economists) Michael Meurer and Jim Bessen concluded (2008) that on average, the patent system discourages innovation. As they write: ?it seems unlikely that patents today are an effective policy instrument to encourage innovation overall? (p. 216). To the contrary, it seems clear that nowadays ?patents place a drag on innovation? (p. 146). In short, ?the patent system fails on its own terms? (p. 145).

And in a recent draft paper (2012), economists Michele Boldrin and David Levine state:

The case against patents can be summarized briefly: there is no empirical evidence that they serve to increase innovation and productivity, unless the latter is identified with the number of patents awarded?which, as evidence shows, has no correlation with measured productivity. This is at the root of the ?patent puzzle?: in spite of the [enormous] increase in the number of patents and in the strength of their legal protection we have neither seen a dramatic acceleration in the rate of technological progress nor a major increase in the levels of R&D expenditurein addition to the discussion in this paper, see Lerner [2009] and literature therein. As we shall see, there is strong evidence, instead, that patents have many negative consequences.

What about lawyers and legal scholars? Well, among practicing lawyers, some of whom pose as scholars, the most vociferous ones tend to be those who know a bit about patent or IP law. Those tend to be practitioners who are naturally biased toward supporting this system; it pays the bills. So it?s no surprise most IP practitioners come up with arguments in favor of patent or copyright, when pressed; but they argue like lawyers, which is to say: like advocates pressing a case, instead of scholars or scientists trying to find the truth; and like unprincipled, ignoramus utilitarians. ?So of course we have a slew of IP apologists and shills?patent lawyers like?Dale Halling, ?Gene Quinn,?Lawrence Ebert, and John Harris. They never have any real arguments; they might as well say, ?we make money from this system and like it!? Which is hard to disagree with, but is ? not an argument for maintaining the IP system. Still, despite the pressure on IP specialists to toe the line, most never try to justify it, many realize that arguments in favor of it are flawed, and a brave few actually come out openly in opposition.

But there seems to be a growing tide of law professors and other legal scholars who are deeply suspicious of patent and copyright and who favor drastic scaling back of these laws if not outright abolition. Such as:

(If anyone knows of any notable anti-IP or IP-skeptical legal scholars I have left off this list, please let me know.)

Unfortunately, most of these scholars are mired in an empiricist-positivist-monist-utilitarian mindset. But they manage to lean in the right direction anyway. Most impressive.

Interestingly, the two notable exceptions to this trend that come to mind and who are pro-IP, are libertarian law professor Richard Epstein and Objectivist Adam Mossoff. But this, too, shall pass.

Source: http://c4sif.org/2012/10/legal-scholars-thumbs-down-on-patent-and-copyright/

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The Story of Scrattch: One of the World's Most Innovative Startups ...

Guest post by?Louise Donnelly-Davey, serial entrepreneur and Founder of?Scrattch, a platform which?seeks to streamline the way users search, store and share the vast amount of information accessed each day across the internet through the application of an online virtual filing system. Scrattch has just been named in the GEW 50,?a list of the world's 50 most innovative new companies, compiled by the?Global Entrepreneurship Week?as part of the?Startup Open, a competition that recognizes startups with high-growth potential.

We were thrilled to be named in the GEW 50?last week?as one of the only companies from New Zealand featured.?

I had the idea for Scrattch over 12 months ago and have been working on it ever since. I have since added two new co-founders (developers) to the team and we are set for launch at the end of this month.?

Before having children (I now have three aged ten and under) I spent a fair bit of time at University. I don?t think I really ever knew exactly what I wanted to do or be. Nothing seemed to fit. I ended up with qualifications in Criminology, Education and Public Policy after spending a total of 6 years at Uni. I then went on to work for various corporates, none of which provided me with any significant fulfillment.?

After the birth of my second child I started my first real business, a clothing design company. We did well and after reaching an international market I decided that the overheads were far too high and that this particular venture, although fun, was never going to enable myself and my family to be financially secure.

I went on to create a successful online social network for people in the kids product industry, which was subsequently sold and is still going today.

After the sale of my social network I felt lost. And it wasn?t until myself and a friend embarked on an online magazine MAEVE, for the 30-40 year old female demographic that I felt right again. It was then that I realized that I needed to be creating something, that I was not fulfilled when I wasn?t being innovative. MAEVE was sold and I then went on to create Scrattch.?

A bit about what we are doing...?

We saw a problem... one which was frustrating and one which was not being tackled properly by any other bookmarking or archiving platforms.

Imagine an International library, whereby anyone could donate books, magazines, videos or any manner of data to the general pool of information available. Next, imagine that the curator of this International library was never allowed to organsise, categorise or file any of the donated material into any sort of semblance for users to browse. The curator was simply allowed to accept information and pile it up, row after row, floor to ceiling. Every now and then he was allowed to promote a few items that he considered interesting or that people had paid him to keep at the front.?

Every time a user entered the library to search for a book or another piece of information they would struggle through the first two rows of the available material, perhaps they would find what they wanted, perhaps they wouldn?t. They eagerly grabbed at some of the items that the curator had highlighted in the hope that this would satisfy their needs.

The internet is not dissimilar. 22 years in the making. Each and every day new data gets added to the mounting repository of information.

Each and every day a user will attempt to find information that best matches their requirements. Unfortunately, the material that is returned on searches is often lacking in relevance and substance.? But we accept that the traditional search engines hold the answers to our needs.?

Our solution.... Scrattch ? Search. Store. Share is an online research, storage and sharing system designed to streamline the way internet users search, store and share the vast amount of information accessed each day across the internet.?

The massive amounts of data we consume each day on the internet is hard to keep track of, URL?s get moved, sites get archived or deleted, important information is often lost in amongst the chaos. More than one billion new pages are added to the Internet each day. In just 60 seconds more than 1500 blog posts, 600 YouTube videos and 6,600 Flickr photos are added to the mounting repository of data available online.?

Lots of noise. How do you find the message??

Scrattch alleviates this pain by enabling users to add their favourite web findings to their own virtual library, then share their favourites with others in the Scrattch community or keep their findings private. Scrattch also allows users to add their own unique content to their Scrattch library, create or join groups within the community and form discussions around topics of interest.

Scrattch is about bringing people together in a social forum over common interests and not common friends.?

Scrattch differs from many other bookmarking, archiving and data storage systems in many ways. Scrattch is leveraged for maximum social interaction, Scrattch enables the user to add their own unique content, take their content offline and; Scrattch is built on a simple platform which is easy to learn and intuitive to use. Scrattch is aimed at the educated internet browser, someone who regularly searches for great content on the net and who is confident in the web 2.0, semantic web or social media.?

Scrattch is fundamentally dedicated to creating meaningful context around your most important data. We are passionate about our mission. We see the internet as it is today as a throw away society.

We want to change the way people interact with the web. Bringing back a sense of ownership and contentment, quality over quantity.

We have had a busy year, being finalists in the ANZ Business Plan Competition and finalists in the Unlimited Magazine (Fairfax) Investment Challenge. As a result of the Investment Challenge we will be pitching to a group of investors at the end of this month.

And we have not even launched yet.

Louise has a degree in Criminology and a Masters in Public Policy, has successfully exited 3 businesses and is the original Founder of Scrattch, launching at the end of October 2012. Prior to stepping out on her own she worked for some of New Zealand's biggest corporates in New Ventures and started her professional career as an intern at the Ministry of Economic Development in their CapitalMarkets team. ?Lou has 3 children 10 and under and spends her weekends at the local ski fields.

Source: http://www.thenextwomen.com/2012/10/23/story-scrattch-one-worlds-most-innovative-startups

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Today's Step-Parenting Links for October 24, 2012 - Blending families

Welcome to "Hey, Mom and Dad"?a weekly feature in which we ask our Facebook fans to share their views on parenting. Every week, we get the conversation started by taking a look back at a question we asked parents the week before on Patch Facebook ?
See all stories on this topic ?

Source: http://www.blending-families.com/blog/parenting/todays-step-parenting-links-for-october-24-2012/

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Gaza rockets draw Israeli strikes; 2 Gazans die

Medics carry a man wounded by a mortar shell fired from the Gaza Strip, for treatment in Soroka hospital in Beersheba, southern Israel, Wednesday, Oct. 24, 2012. Rockets and mortars from Gaza have pummeled southern Israel, drawing Israeli airstrikes that killed a Palestinian militant. Israeli police say more than 30 rockets and mortars landed in Israel early Wednesday, following a volley the night before. (AP Photo /Dudu Grunshpan) ISRAEL OUT

Medics carry a man wounded by a mortar shell fired from the Gaza Strip, for treatment in Soroka hospital in Beersheba, southern Israel, Wednesday, Oct. 24, 2012. Rockets and mortars from Gaza have pummeled southern Israel, drawing Israeli airstrikes that killed a Palestinian militant. Israeli police say more than 30 rockets and mortars landed in Israel early Wednesday, following a volley the night before. (AP Photo /Dudu Grunshpan) ISRAEL OUT

An Israeli military officer surveys the damage of house after a rocket fired by Palestinian militants hit a community along the Israel-Gaza Border, southern Israel, Wednesday, Oct. 24, 2012. Rockets and mortars from Gaza have pummeled southern Israel, drawing Israeli airstrikes that killed a Palestinian militant. The Israeli military said 60 rockets and mortars were fired by early morning Wednesday, following a volley the night before and that Israeli aircraft struck Gaza three times. (AP Photo/Ariel Schalit)

An Israeli soldier surveys the damage to a house after a rocket fired by Palestinian militants from Gaza Strip hit a community in southern Israel, Wednesday, Oct. 24, 2012. Rockets and mortars from Gaza have pummeled southern Israel, drawing Israeli airstrikes that killed a Palestinian militant. The Israeli military said 60 rockets and mortars were fired by early morning Wednesday, following a volley the night before and that Israeli aircraft struck Gaza three times. (AP Photo/ Tsafrir Abayov)

An Israeli woman surveys the damage to a house after a rocket fired by Palestinian militants from Gaza Strip hit a community in southern Israel, Wednesday, Oct. 24, 2012. Rockets and mortars from Gaza have pummeled southern Israel, drawing Israeli airstrikes that killed a Palestinian militant. The Israeli military said 60 rockets and mortars were fired by early morning Wednesday, following a volley the night before and that Israeli aircraft struck Gaza three times. (AP Photo/ Tsafrir Abayov)

An Israeli police sapper holds the remains of a rocket rocket fired by Palestinian militants after it hit a community along the Israel Gaza Border, southern Israel, Wednesday, Oct. 24, 2012. Rockets and mortars from Gaza have pummeled southern Israel, drawing Israeli airstrikes that killed a Palestinian militant. The Israeli military said 60 rockets and mortars were fired early morning Wednesday, following a volley the night before and that Israeli aircraft struck Gaza three times. (AP Photo/Ariel Schalit)

JERUSALEM (AP) ? Gaza militants pummeled southern Israel with dozens of rockets and mortars on Wednesday, and Israeli airstrikes killed two Palestinians in a sharp escalation of violence following a landmark visit to the coastal territory by the leader of Qatar.

Hostilities have been simmering for weeks, but erupted into barrages from Gaza immediately after the Qatari ruler left the territory Tuesday. Militants from the ruling Hamas movement joined the fray, undercutting the emir's appeal to avoid confrontation with Israel.

Israeli leaders vowed that their country would not reconcile itself to attacks from the coastal strip.

"We didn't ask for this escalation and didn't initiate it," Prime Minister Benjamin Netanyahu said after touring a missile defense battery. "But if it continues, we are prepared to embark on a far more extensive and penetrating operation."

Asked if Israel was considering a ground operation in the Palestinian territory, Defense Minister Ehud Barak told Israel Radio that "if we need a ground operation there will be a ground operation. We will do whatever necessary to stop this wave" of violence.

The Israeli military said 72 rockets and mortars landed in Israel by mid-afternoon, and that Israeli aircraft struck Gaza four times.

Hamas' military wing and a smaller militant faction claimed credit for the rocket and mortar fire.

The smaller group ? the Popular Resistance Committees ? said one of its members died in one of the airstrikes, and Gaza health official Dr. Ashraf al-Kidra said another Gaza man died of wounds sustained in an attack Tuesday night that killed two militants. No militant group claimed him as a member.

The deaths brought to four the number of Palestinians who have died in strikes on Gaza in the past two days.

Two foreign workers in Israel were critically wounded in the rocket fire Wednesday, and a number of militants were injured in the Israeli air attacks, Israeli and Palestinian health officials said. Hamas security forces were ordered to evacuate their facilities for fear they would become targets of Israeli airstrikes, and some schools in southern Israel and Gaza canceled classes.

One of the rockets hit a house, causing no injuries, and one of the airstrikes struck a mosque in the southern Gaza village of Khouza for the second time in several weeks.

Crossings between Gaza and Israel were shut down following the exchanges of fire.

Hamas has largely stayed out of direct confrontation with Israel since a major Israeli offensive in Gaza four years ago inflicted heavy casualties and damage, and halted much of the rocket fire. But it is also under pressure from various militant groups, including al-Qaida-inspired Salafis active in Gaza, to prove it remains in confrontation with Israel, whose existence it rejects.

The Qatari emir, Sheik Hamad bin Khalifa Al Thani, had urged the Iranian-backed Hamas to do everything possible to avoid violence with Israel.

But the emir's visit and promise of $400 million in aid bolstered Hamas' flagging popularity and might have encouraged it to join the latest round of hostilities, which had previously involved smaller militant groups.

"These holy missions come in response to the repeated, continuous crimes of the enemy against our people, which killed four and injured 10 in the past 48 hours," the military wing of Hamas and the Popular Resistance Committees said in a statement.

___

Associated Press writers Ibrahim Barzak and Diaa Hadid in Gaza City, Gaza Strip, contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/cae69a7523db45408eeb2b3a98c0c9c5/Article_2012-10-24-Israel-Palestinians/id-7ce626b5336e41bf8daed46054ec2a80

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What Mitt Romney needs to do at the final debate

Political Punch

Tonight's third and final presidential debate will focus entirely on international politics and foreign policy. ?Expect?Benghazi to be one of the major issues, a subject on which, for the first time in nearly a month, the Obama administration will have the upper hand.

"The Romney campaign had the high ground on this issue for weeks. They lost that high ground at the second debate by alleging, suggesting the Obama administration had misled the American public on Benghazi," says Josh Rogin, of Foreign Policy's The Cable.

"It took the president 14 days before he called the attack on the embassy an act of terror," Republican presidential candidate Mitt Romney said at that debate. Obama had in fact called it an act of terror the day after the attack, though the administration spent the next two weeks avoiding the term terror, blaming the attack ?on an anti-Muslim video and claiming some of it was spontaneous.

Still, "there's no real evidence that they misled, it's possible they were just wrong. And President Obama seized on that and called that offensive and...now the president has regained the moral high authority on this issue."

"Of course the administration's argument that they were just incompetent and not misleading is not a perfect argument," says Rogin with a laugh, "but that's the one they're going with."

At tonight's debate Romney will have to focus on the fact "that the administration did make intelligence mistakes and security mistakes in the lead up to the attack, and the communication and messaging mistakes in the follow-up after the attack," says Rogin.

Tune in to ABCNews.com tonight for livestreaming coverage of the final 2012 Presidential Town Hall Debate in Boca Raton, Fla.

Beyond Benghazi, Rogin says Romney will make the case that there is a clear contrast between him and President Obama on three big issues: The use of American power abroad, its stance with Israel, and defense spending and the future of the nation's military spending.

Obama, however, has sent more troops to Afghanistan and involved the United States in Libya. Obama may be more multilateral than others would be, but the United States remains a player on the world stage.

"There's a gap here between Romney's rhetoric and the policies that he would set out that would actually be different from the Obama administration," says Rogin. "If you look at specific issues like Iran, Syria, Afghanistan, what a Romney administration would do if elected is not so different from what the Obama administration is doing right now, which is a very centrist, realist approach to national security."

What the Romney campaign does do, is blame the Obama administration for not doing enough.

"It's their creative sort of way of saying that our policies going forward aren't much different, but they somehow would have been more effective had they been in office," says Rogin.

For more, check out this week's episode of Political Punch.

Source: http://news.yahoo.com/blogs/power-players-abc-news/romney-needs-tonight-foreign-policy-debate-105750153.html

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(10/21) GOOD-EPIC: SOUTHERN CALIFORNIA

Sorry, Readability was unable to parse this page for content.

Source: http://feedproxy.google.com/~r/surfline-rss-surf-news/~3/YA4h2grGUGg/

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Aggressive brain tumors can originate from a range of nervous system cells

Public release date: 22-Oct-2012
[ | E-mail | Share ]

Contact: Andy Hoang
ahoang@salk.edu
619-861-5811
Salk Institute

Salk discovery may help doctors slow progression and recurrence of brain cancer

LA JOLLA, CA---- Scientists have long believed that glioblastoma multiforme (GBM), the most aggressive type of primary brain tumor, begins in glial cells that make up supportive tissue in the brain or in neural stem cells. In a paper published October 17 in Science, however, researchers at the Salk Institute for Biological Studies have found that the tumors can originate from other types of differentiated cells in the nervous system, including cortical neurons.

GBM is one of the most devastating brain tumors that can affect humans. Despite progress in genetic analysis and classification, the prognosis of these tumors remains poor, with most patients dying within one to two years of diagnosis. The Salk researcher's findings offer an explanation for the recurrence of GBM following treatment and suggest potential new targets to treat these deadly brain tumors.

"One of the reasons for the lack of clinical advances in GBMs has been the insufficient understanding of the underlying mechanisms by which these tumors originate and progress," says Inder Verma, a professor in Salk's Laboratory of Genetics and the Irwin and Joan Jacobs Chair in Exemplary Life Science.

To better understand this process, Verma's team harnessed the power of modified viruses, called lentiviruses, to disable powerful tumor suppressor genes that regulate the growth of cells and inhibit the development of tumors. With these tumor suppressors deactivated, cancerous cells are given free rein to grow out of control.

To do that, Verma and his colleagues attached small RNA molecules, known as short hairpin RNAs, to the modified viruses and injected them directly into very few cells in the brains of genetically engineered mice that express an enzyme known as CRE specifically in neurons, astrocytes or neural stem cells. The modified viruses target two genes----neurofibromatosis 1 (NF1) and p53----that, when mutated, are implicated in severe gliomas like GBM. Using sophisticated analytical techniques, they discovered that neurons genetically converted by the lentiviruses that also produce green fluorescent protein (GFP) as a marker to track the progression of tumors are capable of forming malignant gliomas.

Because the origin of glioblastomas from neurons has not been previously reported, the Salk scientists provided further evidence that mature neurons can be transformed by these oncogenes by isolating cortical neurons from genetically engineered mice and transducing them with one of the lentiviruses. The neurons that were transplanted back into the mice developed the same tumors as the ones in the laboratory.

"Our findings," says lead author Dinorah Friedmann-Morvinski, a postdoctoral researcher in the Laboratory of Genetics, "suggest that, when two critical genes----NF-1 and p53----are disabled, mature, differentiated cells acquire the capacity to reprogram [dedifferentiate] to a neuroprogenitor cell-like state, which can not only maintain their plasticity, but also give rise to the variety of cells observed in malignant gliomas."

If scientists can block the process of dedifferentiation or proliferation of dedifferentiated neuroprogenitor cells, they may be able to stop tumor progression. That's important in an aggressive disease like GBM because of its high rate of recurrence.

"Our results offer an explanation of recurrence of gliomas following treatment," says Verma, "because any tumor cell that is not eradicated can continue to proliferate and induce tumor formation, thereby perpetuating the cycle of continuous cell replication to form malignant gliomas."

The scientists say the tumors in their mouse model are similar to GBMs that affect humans. Because they have the same pathology and characteristic genetic signature, scientists can study potential therapies in mice that should, theoretically, work in humans. While they may not eradicate GBM, these therapies may slow the progression of the disease and improve patients' quality of life.

###

Other researchers on the study were Eugene Ke, Yasushi Soda, Tomotoshi Marumoto and Oded Singer of the Salk Institute; and Eric Bushong and Mark Ellisman of the University of California, San Diego.

The work was supported by the National Institutes of Health, Ipsen/Biomeasure, the Leona M. and Harry B. Helmsley Charitable Trust, the H.N. and Frances C. Berger Foundation, and the National Center for Research Resources.

About the Salk Institute for Biological Studies:

The Salk Institute for Biological Studies is one of the world's preeminent basic research institutions, where internationally renowned faculty probe fundamental life science questions in a unique, collaborative, and creative environment. Focused both on discovery and on mentoring future generations of researchers, Salk scientists make groundbreaking contributions to our understanding of cancer, aging, Alzheimer's, diabetes and infectious diseases by studying neuroscience, genetics, cell and plant biology, and related disciplines.

Faculty achievements have been recognized with numerous honors, including Nobel Prizes and memberships in the National Academy of Sciences. Founded in 1960 by polio vaccine pioneer Jonas Salk, M.D., the Institute is an independent nonprofit organization and architectural landmark.

---

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?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 22-Oct-2012
[ | E-mail | Share ]

Contact: Andy Hoang
ahoang@salk.edu
619-861-5811
Salk Institute

Salk discovery may help doctors slow progression and recurrence of brain cancer

LA JOLLA, CA---- Scientists have long believed that glioblastoma multiforme (GBM), the most aggressive type of primary brain tumor, begins in glial cells that make up supportive tissue in the brain or in neural stem cells. In a paper published October 17 in Science, however, researchers at the Salk Institute for Biological Studies have found that the tumors can originate from other types of differentiated cells in the nervous system, including cortical neurons.

GBM is one of the most devastating brain tumors that can affect humans. Despite progress in genetic analysis and classification, the prognosis of these tumors remains poor, with most patients dying within one to two years of diagnosis. The Salk researcher's findings offer an explanation for the recurrence of GBM following treatment and suggest potential new targets to treat these deadly brain tumors.

"One of the reasons for the lack of clinical advances in GBMs has been the insufficient understanding of the underlying mechanisms by which these tumors originate and progress," says Inder Verma, a professor in Salk's Laboratory of Genetics and the Irwin and Joan Jacobs Chair in Exemplary Life Science.

To better understand this process, Verma's team harnessed the power of modified viruses, called lentiviruses, to disable powerful tumor suppressor genes that regulate the growth of cells and inhibit the development of tumors. With these tumor suppressors deactivated, cancerous cells are given free rein to grow out of control.

To do that, Verma and his colleagues attached small RNA molecules, known as short hairpin RNAs, to the modified viruses and injected them directly into very few cells in the brains of genetically engineered mice that express an enzyme known as CRE specifically in neurons, astrocytes or neural stem cells. The modified viruses target two genes----neurofibromatosis 1 (NF1) and p53----that, when mutated, are implicated in severe gliomas like GBM. Using sophisticated analytical techniques, they discovered that neurons genetically converted by the lentiviruses that also produce green fluorescent protein (GFP) as a marker to track the progression of tumors are capable of forming malignant gliomas.

Because the origin of glioblastomas from neurons has not been previously reported, the Salk scientists provided further evidence that mature neurons can be transformed by these oncogenes by isolating cortical neurons from genetically engineered mice and transducing them with one of the lentiviruses. The neurons that were transplanted back into the mice developed the same tumors as the ones in the laboratory.

"Our findings," says lead author Dinorah Friedmann-Morvinski, a postdoctoral researcher in the Laboratory of Genetics, "suggest that, when two critical genes----NF-1 and p53----are disabled, mature, differentiated cells acquire the capacity to reprogram [dedifferentiate] to a neuroprogenitor cell-like state, which can not only maintain their plasticity, but also give rise to the variety of cells observed in malignant gliomas."

If scientists can block the process of dedifferentiation or proliferation of dedifferentiated neuroprogenitor cells, they may be able to stop tumor progression. That's important in an aggressive disease like GBM because of its high rate of recurrence.

"Our results offer an explanation of recurrence of gliomas following treatment," says Verma, "because any tumor cell that is not eradicated can continue to proliferate and induce tumor formation, thereby perpetuating the cycle of continuous cell replication to form malignant gliomas."

The scientists say the tumors in their mouse model are similar to GBMs that affect humans. Because they have the same pathology and characteristic genetic signature, scientists can study potential therapies in mice that should, theoretically, work in humans. While they may not eradicate GBM, these therapies may slow the progression of the disease and improve patients' quality of life.

###

Other researchers on the study were Eugene Ke, Yasushi Soda, Tomotoshi Marumoto and Oded Singer of the Salk Institute; and Eric Bushong and Mark Ellisman of the University of California, San Diego.

The work was supported by the National Institutes of Health, Ipsen/Biomeasure, the Leona M. and Harry B. Helmsley Charitable Trust, the H.N. and Frances C. Berger Foundation, and the National Center for Research Resources.

About the Salk Institute for Biological Studies:

The Salk Institute for Biological Studies is one of the world's preeminent basic research institutions, where internationally renowned faculty probe fundamental life science questions in a unique, collaborative, and creative environment. Focused both on discovery and on mentoring future generations of researchers, Salk scientists make groundbreaking contributions to our understanding of cancer, aging, Alzheimer's, diabetes and infectious diseases by studying neuroscience, genetics, cell and plant biology, and related disciplines.

Faculty achievements have been recognized with numerous honors, including Nobel Prizes and memberships in the National Academy of Sciences. Founded in 1960 by polio vaccine pioneer Jonas Salk, M.D., the Institute is an independent nonprofit organization and architectural landmark.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2012-10/si-abt102212.php

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Spitzer talks politics in 1st public appearance in Albany since resigning as NY gov. in 2008 (Star Tribune)

Share With Friends: | | Politics - Top Stories Stories, RSS Feeds and Widgets via Feedzilla.

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Fiction 101 Entries Now Being Accepted | Cobweb

Best of Boise Fiction 101 Entries Now Being Accepted

Posted by Deanna Darr on Mon, Oct 22, 2012 at 3:33 PM

Got a knack for telling a compelling story in a teeny tiny time period? Well, it's time to put your words, well, where your words are.

Boise Weekly's annual short fiction writing contest, Fiction 101, is back for its 11th year, which means it's time for writers to start putting their ideas on paper?and then editing the bejesus out of them.

All entries are due at BWHQ no later than 5 p.m. Wednesday, Nov. 7.

Here are the vital statistics you need to know:

? All entries must be exactly 101 words as counted by Microsoft Word (excluding the title).

? All entries must be fiction.

? No poetry allowed.

? No handwritten entries.

? All entries must be accompanied by a $10 per story entry fee.

? All entries must have the authors name, address and phone number on the BACK of each story.

? BW employees and freelancers are not eligible to enter.

Entry fees will be used to award cash prizes to the winners, as selected by an illustrious panel of judges. Those winning entries will be published in the Wednesday, Jan. 2, edition of Boise Weekly.

Entries can be dropped off in person or mailed to Boise Weekly, 523 Broad St., Boise, ID, 83702. For more information, contact Office Manager Shea Sutton at 208-344-2055.

Also, be sure to mark your calendars for a little one-on-one time with our winning authors during First Thursday, Jan. 3. BW is once again teaming up with the crew at Rediscovered Books to host a special reading and question-and-answer session with the winning authors. The reading will begin at 7:30 p.m., but look for more details closer to the event.

Tags: Fiction 101

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'); } else if (jQuery(this).attr("id") == "sortSelect"){ jQuery("#BlogComments .sortSpinner").show(); } var url = "/Cobweb/archives/2012/10/22/fiction-101-entries-now-being-accepted"; var myStart = jQuery(this).attr("id") == "sortSelect" ? "1" : jQuery(this).attr("rel"); var showAllComments = jQuery(this).attr("id") == "showAllComments" ? "yes" : "no"; if (!myStart) var myStart = "1"; var mySort = jQuery("#sortSelect").val() || "asc"; var params = { sort: mySort, ajaxComponent: componentId, startIndex: myStart, showAll: showAllComments }; jQuery.ajax({ url: url, data: (params), success: function (data) { jQuery("#"+componentId+"_PaginationBottom").remove(); jQuery("#"+componentId+"_commentContent .brandNewComment").remove(); jQuery("#BlogComments .sortSpinner").hide(); if (myStart == "1") jQuery("#"+componentId+"_commentContent").html(data); else jQuery("#"+componentId+"_commentContent").append(data); } }); }; function removeEdit(oid){ if (oid){ var cont = jQuery("#BlogComments-comment-"+oid).closest(".brandNewComment"); cont.find(".newCommentOptions").fadeOut("fast", function(){ jQuery(this).remove(); }); } } function getComment(oid){ var url = "/Cobweb/archives/2012/10/22/fiction-101-entries-now-being-accepted"; if (oid){ var params = { ajaxComponent: componentId, commentOid: oid }; jQuery.ajax({ url: url, data: (params), success: function (data) { if (!jQuery.trim(jQuery("#"+componentId+"_commentContent").html())){ jQuery("#"+componentId+"_commentContent").append(data).find(".brandNewComment").fadeIn("fast"); } else { jQuery("#"+componentId+"_commentContent").children("div.comment, div.brandNewComment").filter(":last").after(data).parent().find(".brandNewComment").fadeIn("fast"); } var t=setTimeout(function(){removeEdit(oid)},300000); var myTotal = parseInt(jQuery("#comments_total").text(), 10); myTotal++; updateCommentTotals(false,myTotal); } }); } } function doLikeComment(e){ e.preventDefault(); if (!this.clicked){ var oid = jQuery(this).attr("data-commentOid"); jQuery("#BlogComments #"+oid+"_likeLinks a").addClass("dimmed").css("opacity","0.4").each(function(){this.clicked = true;}); var myCurrentLikes = jQuery("#"+oid+"_rating_likes").html() || 0; var myCurrentDislikes = jQuery("#"+oid+"_rating_dislikes").html() || 0; var thisRating = jQuery(this).attr("rel"); if (thisRating == "Like"){ myCurrentLikes = parseFloat(myCurrentLikes)+1; } else { myCurrentDislikes = parseFloat(myCurrentDislikes)+1; } var myNewLine = '' + myCurrentLikes + ' like'; if (myCurrentLikes != 1) { myNewLine += 's'; } myNewLine += ', ' + '' + myCurrentDislikes + ' dislike'; if (myCurrentDislikes != 1) { myNewLine += "s"; } jQuery("#"+oid+"_rating_sub").html(myNewLine); jQuery("#"+oid+"_rating_sub").show(); var params = { oid: oid, rating: thisRating }; jQuery.ajax({ url: "/gyrobase/Tools/AjaxLike", type: "POST", data: (params), success: function (data) { jQuery("#"+oid+"_rating_sub").html(data); if (thisRating == "Like"){ jQuery("#BlogComments #"+oid+"_likeLinks a.dislike").removeClass("dimmed").css("opacity","1").each(function(){this.clicked = false;}); } else { jQuery("#BlogComments #"+oid+"_likeLinks a.like").removeClass("dimmed").css("opacity","1").each(function(){this.clicked = false;}); } } }); } } function reportComment(e){ e.preventDefault(); e.stopPropagation(); var oid = jQuery(this).attr("rel"); var elem = jQuery("#"+oid+"_report"); elem.click(function(e){e.stopPropagation();}) if (!elem.is(":visible")){ jQuery("#BlogComments .reportCommentContainer").hide(); if (elem.is(":empty")){ var params = { oid: oid, ajaxComponent: "ReportComment" }; jQuery.ajax({ url: "/gyrobase/Tools/ReportComment", data: (params), success: function (data) { elem.html(data); elem.fadeIn("fast"); } }); } else { elem.fadeIn("fast"); } } // attach close event handler to the html jQuery("html").one("click", function(){ jQuery("#BlogComments .reportCommentContainer:visible").hide(); }); } function closeReport(obj){ jQuery(obj).closest(".reportCommentContainer").fadeOut("fast"); } function submitReport(e){ var params = jQuery(e).closest("form").serialize()+"&ajaxComponent=ReportComment"; jQuery.ajax({ url: "/gyrobase/Tools/ReportComment", type: "POST", data: (params), success: function (data) { jQuery(e).closest(".reportCommentContainer").html(data); } }); } (function($) { var subscribed=false; function showFollowPanel(e){ e.preventDefault(); myPanel = $(this).parent().next(".togglePanel"); myPanel.fadeIn("fast"); } function doSubscribe(obj){ var myPanel = obj.parent().next(".togglePanel"); myPanel.fadeIn("fast"); if (!subscribed){ var myLink = obj.parent(); var myLoader = myPanel.children(".loading"); var myUpdater = myPanel.children(".ajaxUpdater"); var params = { object: myPanel.attr("data-toolsoid"), macro: myPanel.attr("data-toolsajaxmacro"), url: window.location }; $.ajax({ url: "/gyrobase/Macros/ToolsAjax", data: (params), type: "POST", dataType: "html", success: function (data) { subscribed = true; if (myUpdater){ myUpdater.html(data); myLoader.fadeOut("fast", function(){ myUpdater.fadeIn("fast", function(){ setTimeout(function(){ myPanel.fadeOut("fast"); }, 3000); }); }); } else { myPanel.fadeOut("fast"); } } }); } } function activateSubscribe(e){ e.preventDefault(); var myObj = $(this); var isAuthenticated = Foundation.SessionManager.sharedSessionManager().isAuthenticated(); if (!isAuthenticated){ new Foundation.Login.Dialog({ "feelingShy": false, "callback": function(){doSubscribe(myObj);} }); return false; } else { // Proceed doSubscribe(myObj); } } function deleteComment(e){ e.preventDefault(); var thisComment = $(this); var params = { macro: "deleteComment", comment: thisComment.attr("data-comment") }; $.ajax({ url: "/gyrobase/Macros/ToolsAjax", data: (params), type: "POST", dataType: "html", success: function (data) { thisComment.closest(".brandNewComment").fadeOut("fast", function(){ $(this).remove(); var myTotal = parseInt(jQuery("#comments_total").text(), 10); myTotal--;console.log(myTotal); updateCommentTotals(false,myTotal); }); } }); } function editComment(e){ e.preventDefault(); var thisComment = $(this); var commentCont = thisComment.closest(".brandNewComment").find(".description"); var commentTemp = thisComment.closest(".brandNewComment").find(".commentTemp"); var commentText = commentTemp.html(); var toolbar = thisComment.closest(".brandNewComment").find(".commentToolbar"); commentCont.next(".commentEditCont").remove(); commentCont.after(''); toolbar.fadeOut("fast"); commentCont.fadeOut("fast", function(){ commentCont.next(".commentEditCont").fadeIn("fast"); }); $(".brandNewComment textarea.expandableBox").autoBoxResize(); } function editCommentSave(e){ e.preventDefault(); var thisComment = $(this); var editCont = thisComment.closest(".commentEditCont"); var commentTemp = thisComment.closest(".brandNewComment").find(".commentTemp"); var newText = thisComment.prevAll("textarea").val(); var toolbar = thisComment.closest(".brandNewComment").find(".commentToolbar"); var params = { macro: "editComment", comment: thisComment.attr("data-comment"), commentText: newText }; $.ajax({ url: "/gyrobase/Macros/ToolsAjax", data: (params), type: "POST", dataType: "html", success: function (data) { editCont.fadeOut("fast", function(){ editCont.prev(".description").html($.trim(data)); commentTemp.html(newText); editCont.prev(".description").fadeIn("fast"); toolbar.fadeIn("fast"); }); } }); } function editCommentCancel(e){ e.preventDefault(); var editCont = $(this).closest(".commentEditCont"); var toolbar = $(this).closest(".brandNewComment").find(".commentToolbar"); editCont.fadeOut("fast", function(){ editCont.prev(".description").fadeIn("fast"); toolbar.fadeIn("fast"); editCont.remove(); }); } $("#BlogComments").on('click', ".bottomOptionBar a#doSubscribe", activateSubscribe); $("#BlogComments").on('click', ".bottomOptionBar a.togglePanelClose", function(){$(this).parent().fadeOut("fast"); return false;}); $("#BlogComments").on('click', ".brandNewComment a.commentDeleteLink", deleteComment); $("#BlogComments").on('click', ".brandNewComment a.commentEditLink", editComment); $("#BlogComments").on('click', ".brandNewComment a.doneEditLink", editCommentSave); $("#BlogComments").on('click', ".brandNewComment a.cancelEditLink", editCommentCancel); })(jQuery); jQuery(document).ready(function($){ $("#BlogComments").on('click', '#showMoreComments,#showAllComments', getMoreComments); $("#BlogComments #sortSelect").change(getMoreComments); getMoreComments(); new Foundation.PostCommentComponent(componentId); var nc = Foundation.NotificationCenter.sharedNotificationCenter(); nc.observe("comment:added", function (e) { var comment = e.data; getComment(comment.get("oid")); // clear rating if (jQuery(".commentFormRating").length!=0){ jQuery(".commentFormRating input[name='reviewRating']").val(""); jQuery(".commentFormRating .goldStarContainer").css("left", zeroPos+"px"); } }); var subscribeCheckBox = $("#BlogComments_commentSubscribe"); subscribeCheckBox.prop("checked", getCookie("subscribeToThread") === "true" ? true : false); subscribeCheckBox.change(function (e) { var subscribeToThread = $(this).prop("checked"); setCookie("subscribeToThread", subscribeToThread ? "true" : "false", 30); }); var shareFacebookBox = $("#BlogComments_postCommentToFacebook"); shareFacebookBox.prop("checked", getCookie("shareOnFacebook") === "true" ? true : false); shareFacebookBox.change(function (e) { var shareOnFacebook = $(this).prop("checked"); setCookie("shareOnFacebook", shareOnFacebook ? "true" : "false", 30); }); $("#BlogComments").on('click', 'a.likeLink', doLikeComment); $("#BlogComments").on('click', 'a.reportCommentLink', reportComment); });

Source: http://www.boiseweekly.com/Cobweb/archives/2012/10/22/fiction-101-entries-now-being-accepted

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