?Modest? BlackBerry Z10 sales, upcoming Galaxy S IV launch could hurt BlackBerry

BlackBerry

A string of upbeat reports has sent BlackBerry?s (BBRY) stock climbing in recent months, but the end is nigh according to one industry watcher.?Canaccord Genuity analyst T. Michael Walkley again tried to chase clients away from BlackBerry shares on Monday, suggesting that ?modest? BlackBerry Z10 sales and big competition from the likes of Samsung?s (005930) Galaxy S IV could spell doom for BlackBerry?s stock in the coming quarters.

[More from BGR: The Boy Genius Report: Sonos? PLAYBAR takes over the living room]

?Our global surveys post the recent BlackBerry Z10 launch indicated mixed initial sales with limited initial supply cited as the reason for early post-launch stock-outs at some carrier stores during the first week of launch,? Walkley wrote in a note to investors on Monday. ?Our follow up surveys have indicated steady but modest sales levels for the Z10.?

[More from BGR: Galaxy S IV specs reportedly confirmed in new benchmarks]

He continued, ?With new BB10 smartphones launching in the U.S. only in mid-March or later at subsidized prices no better than competing high-end Apple/Samsung smartphones combined with our expectations for the Galaxy S IV to launch at a similar time frame in the US market, we anticipate BlackBerry will struggle to reclaim high-end smartphone market share.?

Following his most recent round of checks, Walkley admits that his last BlackBerry Z10 sales estimate was likely too low. His new checks suggest BlackBerry likely sold 800,000 Z10 handsets into channels last quarter, up from his earlier estimate of just 300,000 units.

The positive change will shave $0.12 off of BlackBerry?s estimated full-year loss per share, which the analyst adjusted to $(1.06) from $(1.18), but Walkley?s fiscal 2014 and 2015 estimates remain unchanged. ?BlackBerry will struggle to drive enough BB10 demand to return the company to sustained profitability,? he wrote.

Walkley reiterated his Sell rating on BlackBerry shares with a $9 price target.

This article was originally published on BGR.com

Source: http://news.yahoo.com/modest-blackberry-z10-sales-upcoming-galaxy-iv-launch-154535856.html

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Scientists say baby born with HIV apparently cured

WASHINGTON (AP) ? A baby born with the virus that causes AIDS appears to have been cured, scientists announced Sunday, describing the case of a child from Mississippi who's now 2? and has been off medication for about a year with no signs of infection.

There's no guarantee the child will remain healthy, although sophisticated testing uncovered just traces of the virus' genetic material still lingering. If so, it would mark only the world's second reported cure.

Specialists say Sunday's announcement, at a major AIDS meeting in Atlanta, offers promising clues for efforts to eliminate HIV infection in children, especially in AIDS-plagued African countries where too many babies are born with the virus.

"You could call this about as close to a cure, if not a cure, that we've seen," Dr. Anthony Fauci of the National Institutes of Health, who is familiar with the findings, told The Associated Press.

A doctor gave this baby faster and stronger treatment than is usual, starting a three-drug infusion within 30 hours of birth. That was before tests confirmed the infant was infected and not just at risk from a mother whose HIV wasn't diagnosed until she was in labor.

"I just felt like this baby was at higher-than-normal risk, and deserved our best shot," Dr. Hannah Gay, a pediatric HIV specialist at the University of Mississippi, said in an interview.

That fast action apparently knocked out HIV in the baby's blood before it could form hideouts in the body. Those so-called reservoirs of dormant cells usually rapidly reinfect anyone who stops medication, said Dr. Deborah Persaud of Johns Hopkins Children's Center. She led the investigation that deemed the child "functionally cured," meaning in long-term remission even if all traces of the virus haven't been completely eradicated.

Next, Persaud's team is planning a study to try to prove that, with more aggressive treatment of other high-risk babies. "Maybe we'll be able to block this reservoir seeding," Persaud said.

No one should stop anti-AIDS drugs as a result of this case, Fauci cautioned.

But "it opens up a lot of doors" to research if other children can be helped, he said. "It makes perfect sense what happened."

Better than treatment is to prevent babies from being born with HIV in the first place.

About 300,000 children were born with HIV in 2011, mostly in poor countries where only about 60 percent of infected pregnant women get treatment that can keep them from passing the virus to their babies. In the U.S., such births are very rare because HIV testing and treatment long have been part of prenatal care.

"We can't promise to cure babies who are infected. We can promise to prevent the vast majority of transmissions if the moms are tested during every pregnancy," Gay stressed.

The only other person considered cured of the AIDS virus underwent a very different and risky kind of treatment ? a bone marrow transplant from a special donor, one of the rare people who is naturally resistant to HIV. Timothy Ray Brown of San Francisco has not needed HIV medications in the five years since that transplant.

The Mississippi case shows "there may be different cures for different populations of HIV-infected people," said Dr. Rowena Johnston of amFAR, the Foundation for AIDS Research. That group funded Persaud's team to explore possible cases of pediatric cures.

It also suggests that scientists should look back at other children who've been treated since shortly after birth, including some reports of possible cures in the late 1990s that were dismissed at the time, said Dr. Steven Deeks of the University of California, San Francisco, who also has seen the findings.

"This will likely inspire the field, make people more optimistic that this is possible," he said.

In the Mississippi case, the mother had had no prenatal care when she came to a rural emergency room in advanced labor. A rapid test detected HIV. In such cases, doctors typically give the newborn low-dose medication in hopes of preventing HIV from taking root. But the small hospital didn't have the proper liquid kind, and sent the infant to Gay's medical center. She gave the baby higher treatment-level doses.

The child responded well through age 18 months, when the family temporarily quit returning and stopped treatment, researchers said. When they returned several months later, remarkably, Gay's standard tests detected no virus in the child's blood.

Ten months after treatment stopped, a battery of super-sensitive tests at half a dozen laboratories found no sign of the virus' return. There were only some remnants of genetic material that don't appear able to replicate, Persaud said.

In Mississippi, Gay gives the child a check-up every few months: "I just check for the virus and keep praying that it stays gone."

The mother's HIV is being controlled with medication and she is "quite excited for her child," Gay added.

The United Nations agency that guides the global fight against HIV/AIDS, known as UNAIDS, hailed the news.

"This news gives us great hope that a cure for HIV in children is possible and could bring us one step closer to an AIDS-free generation," said UNAIDS Executive Director Michel Sidibe. "This also underscores the need for research and innovation especially in the area of early diagnostics."

___

Associated Press writer Ron DePasquale contributed from the United Nations in New York.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2013-03-04-HIV-Baby%20Cure?/id-89f2a112e97840c8af7a2212cdddf62c

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Prehistoric warming linked to CO2

A study of 20,000- to 10,000-year-old?Antarctic ice indicates that a rise in temperatures was driven by natural carbon dioxide emissions. ??

By Tia Ghose,?LiveScience Staff Writer / February 28, 2013

A section of an Antarctic ice core shown under polarized light reveals the individual ice crystals.

Fr?d?ric Parrenin

Enlarge

Rising carbon dioxide levels may have caused Antarctic warming in the past, new research strongly suggests.

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The findings, published today (Feb. 28) in the journal Science, just add to the body of evidence that human-caused greenhouse gas emissions will lead to?climate change.

"It's new evidence from the past of the strong role of CO2 [carbon dioxide] in climate variation," said study co-author Fr?d?ric Parrenin, a climate scientist at the CNRS in France.

Past data

Eons of the Earth's climate history are revealed deep within ice sheets in the Arctic and Antarctic. The?Antarctic ice?traps gas bubbles from the climate that can reveal what the ancient atmosphere looked like, while the ice itself can reveal historical temperatures.

But gas bubbles from a given period get buried deeper than ice of the same period, making it hard to tie past temperatures with atmospheric changes.

In the past, scientists using older techniques found that increases in carbon dioxide happened after global warming, not the reverse. [Images of Melt: Earth's Vanishing Ice]

Past link

But Parrenin and his colleagues wondered whether that was actually the case. To answer that question, the team looked at five ice cores that had been drilled from?Antarctica?over the last 30 years.

They focused on ice from 20,000 to 10,000 years ago, which encompassed the last period when the planet warmed naturally and glaciers melted.

The team measured the concentration of nitrogen-15 isotopes, or atoms of the same element with different weights, at different depths throughout the?ice cores. They compared the depth of that isotope with the ice composition for all the cores to determine the distance between ice bubbles and ice from the same period.

Global warming

The team found that global warming and a carbon dioxide increase happened at virtually the same time ? between 18,000 and 11,000 years ago.

"It makes it possible that CO2 was the cause ? at least partly ? of the temperature increase during the courses of the last glaciation," Parrenin told LiveScience.

And if increased carbon dioxide could lead to?rising temperatures?in the past, it also can in the present day, he said.

The findings may deflate some?climate skeptics, who used the poor dating of ice cores to question the link between carbon dioxide and warming, said Robert Mulvaney, a glaciologist with the British Antarctic Survey, who was not involved in the study.

It also confirmed the view of most climate scientists that in the past, rising temperatures and carbon dioxide were locked in a feedback loop, where high temperatures led to more carbon dioxide being released from the deep oceans, which increased temperatures further, Mulvaney said.

But because predictions of future warming are based on recent carbon dioxide and temperature data, not historical models, "it hasn't really changed anything about our understanding of how climate change will change our modern environment." Mulvaney told LiveScience.

Follow Tia Ghose on Twitter?@tiaghose?or LiveScience?@livescience. We're also on?Facebook?&?Google+.?

Copyright 2013?LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://rss.csmonitor.com/~r/feeds/science/~3/FiFotxCyB74/Prehistoric-warming-linked-to-CO2

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There Was That Whole Internet Thing, Too

Anyone wanting to see the whole “history is written by the victors” thing in process should read Tim Wu and John Gruber battle it out over exactly why Apple has kicked the crap out of everyone else since the late 90s. Wu, who’s confused about what open v. closed systems really mean (he uses a variety of definitions), says that Apple has succeeded despite being a closed system. Gruber says open v. closed doesn’t matter, and says Apple succeeds because it produces great products fast (meaning first to market). Gruber’s argument can be condensed down to “Companies run by geniuses should generally do better than those which are not,” and I agree. Except. The internet. Talking about Apple v. Microsoft without mentioning the internet and the browser is like talking about WWII without talking about the nuke. Framing the conversation just in terms of open v. closed operating systems, the quality of the hardware or software or who the CEO was, is silly. Because without the internet happening there’s no way Apple would have succeeded. Before the internet all most people cared about was Office. And Office was really the only reason anyone wanted Windows machines instead of Macs. I remember endless Apple v. Windows debates in the early 90s when I was in college. Macs were better machines, everyone said, the whole Office thing was a huge pain. It was difficult to transfer files between operating systems, and generally speaking if you wanted to do Office stuff you needed a Windows machine. Macs were for college kids doing graphics stuff. Windows machines were for grown ups. That all changed in the mid 90′s of course. But before people bought computers primarily to get on the Internet Apple was hurting badly. Market share was so bad there was even a question about whether Microsoft would even continue making Office for Mac. Then everything came together for Apple at roughly the same time. Steve Jobs came back in 1997. He got Microsoft to recommit to Office on the Mac. From Wikipedia: At the 1997 Macworld Expo, Steve Jobs announced that Apple would be entering into a partnership with Microsoft. Included in this was a five-year commitment from Microsoft to release Microsoft Office for Macintosh as well as a US$150 million investment in Apple. As part of the deal Apple and Microsoft agreed to settle a long-standing dispute over whether Microsoft’s Windows

Source: http://feedproxy.google.com/~r/Techcrunch/~3/0OlHTliOT1s/

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Tamed Dragon supply ship arrives at space station

This frame grab made available by NASA TV shows a view of the SpaceX Dragon capsule on the end of the International Space Station's robotic arm, Sunday, March 3, 2013. SpaceX, the California-based company founded by billionaire Elon Musk, had to struggle with the Dragon following its launch Friday from Cape Canaveral. The spacecraft is delivering more than 1 ton of supplies to the the International Space Station. (AP Photo/NASA TV)

This frame grab made available by NASA TV shows a view of the SpaceX Dragon capsule on the end of the International Space Station's robotic arm, Sunday, March 3, 2013. SpaceX, the California-based company founded by billionaire Elon Musk, had to struggle with the Dragon following its launch Friday from Cape Canaveral. The spacecraft is delivering more than 1 ton of supplies to the the International Space Station. (AP Photo/NASA TV)

This frame grab made available by NASA TV shows a view of the SpaceX Dragon anchoring to the International Space Station Sunday, March 3, 2013. SpaceX, the California-based company founded by billionaire Elon Musk, had to struggle with the Dragon following its launch Friday from Cape Canaveral. The spacecraft is delivering more than 1 ton of supplies to the the International Space Station. (AP Photo/NASA TV)

CAPE CANAVERAL, Fla. (AP) ? A privately owned Dragon capsule arrived at the International Space Station on Sunday, delivering a ton of supplies with high-flying finesse after a shaky start to the mission.

The Dragon's arrival was one day late but especially sweet ? and not because of the fresh fruit on board for the station astronauts who snared the capsule.

SpaceX, the California-based company founded by billionaire Elon Musk, had to struggle with the Dragon following its launch Friday from Cape Canaveral. A clogged pressure line or stuck valve prevented thrusters from working, and it took flight controllers several hours to gain control and salvage the mission.

In the end, the Dragon approached the orbiting lab with its 1-ton load about as smoothly as could be expected, with all of its thrusters, or little maneuvering rockets, operating perfectly. The capture occurred as the two spacecraft zoomed 250 miles above Ukraine.

"As they say, it's not where you start, but where you finish that counts," said space station commander Kevin Ford, "and you guys really finished this one on the mark."

He added: "We've got lots of science on there to bring aboard and get done. So congratulations to all of you."

Among the items on board: 640 seeds of a flowering weed used for research, mouse stem cells, food and clothes for the six men on board the space station, trash bags, computer equipment, air purifiers, spacewalking tools and batteries. The company also tucked away apples and other fresh treats from an employee's family orchard.

The Dragon will remain at the space station for most of March before returning to Earth with science samples, empty food containers and old equipment.

SpaceX ? Space Exploration Technologies Corp. ? has a $1.6 billion contract with NASA to keep the station well stocked. The contract calls for 12 supply runs; this was the second in that series.

This is the third time, however, that a Dragon has visited the space station. The previous two capsules had no trouble reaching their destination. Company officials promise a thorough investigation into what went wrong this time; if the thrusters had not been activated, the capsule would have been lost.

Ford said everything about Sunday's rendezvous ended up being "fantastic."

"There sure were some big smiles all around here," NASA's Mission Control replied from Houston.

The actual anchoring of the Dragon to the space station, 2? hours after its arrival, also unfolded without a hitch. "The Dragon is ours!" Canadian astronaut Chris Hadfield announced via Twitter.

In a tweet following Friday's nerve-racking drama, Musk said, "Just want to say thanks to (at)NASA for being the world's coolest customer. Looking forward to delivering the goods!"

Musk, who helped create PayPal, acknowledged Friday that the problem ? the first ever for an orbiting Dragon ? was "frightening." But he believed it was a one-time glitch and nothing so serious as to imperil future missions. The 41-year-old entrepreneur, who also runs the electric car maker Tesla, oversaw the entire operation from Hawthorne, Calif., home to SpaceX and the company's Mission Control.

The Dragon's splashdown in the Pacific, meanwhile, remains on schedule for March 25.

NASA is counting on the commercial sector to supply the space station for the rest of this decade; it's supposed to keep running until at least 2020. Russia, Europe and Japan are doing their part, periodically launching their own cargo ships. But none of those craft can return items like the Dragon can; they burn up on re-entry

Russia also is providing rides for U.S. astronauts.

SpaceX and other companies are working toward launching astronauts in another few years. Musk leads the charge; he said he can have people flying on a modified Dragon by 2015.

NASA's space shuttles, retired to museums after a 30-year run, used to be the main haulers for the space station. At the White House direction, the space agency opted out of the Earth-to-orbit transportation business in order to focus on deep space exploration. Mars is the ultimate destination.

___

Online:

NASA: http://www.nasa.gov/mission_pages/station/structure/launch/index.html

SpaceX: http://www.spacex.com/

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-03-03-US-SCI-Private-Space/id-4b7cc340f2104aa9b5a43d6909359a51

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Where the wild things go? when there's nowhere else

Public release date: 28-Feb-2013
[ | E-mail | Share ]

Contact: Morgan Kelly
mgnkelly@princeton.edu
609-258-5729
Princeton University

Ecologists have evidence that some endangered primates and large cats faced with relentless human encroachment will seek sanctuary in the sultry thickets of mangrove and peat swamp forests. These harsh coastal biomes are characterized by thick vegetation particularly clusters of salt-loving mangrove trees and poor soil in the form of highly acidic peat, which is the waterlogged remains of partially decomposed leaves and wood. As such, swamp forests are among the few areas in many African and Asian countries that humans are relatively less interested in exploiting (though that is changing).

Yet conservationists have been slow to consider these tropical hideaways when keeping tabs on the distribution of threatened animals such as Sumatran orangutans and Javan leopards, according to a recent Princeton University study in the journal Folia Primatologica. To draw attention to peat and mangrove swamps as current and possibly future wildlife refuges, Katarzyna Nowak, a former postdoctoral researcher of ecology and evolutionary biology at Princeton, compiled a list of 60 primates and 20 felids (the large-cat family that includes tigers and leopards) known to divide their time between their natural forest habitats and some 47 swamp forests in Africa and Asia.

[Images can be seen at http://blogs.princeton.edu/research/2013/02/28/where-the-wild-things-go-folia-primatologica/. To obtain high-res images, contact Princeton science writer Morgan Kelly, (609) 258-5729, mgnkelly@princeton.edu]

Because swamp forests often lack food sources, fresh water and easy mobility, few mammals are exclusive to these areas, Nowak reported. Consequently, conservation groups have not intensely monitored the animals' swamp use.

But the presence of endangered cats and primates in swamp forests might be seriously overlooked, Nowak found. About 55 percent of Old World monkeys primates such as baboons and macaques that are native to Africa and Asia take to the swamps either regularly, seasonally or as needed. In 2008, the Wildlife Conservation Society reported that the inaccessible Lake Tl swamp forest in the Republic of the Congo was home to 125,000 lowland gorillas more than were thought to exist in the wild. Among big cats, the Bengal tiger, for instance, holds its sole ground in Bangladesh in the Sundarbans, the world's largest mangrove forest.

Life in the swamps can still be harsh for some animals. Species such as the crab-eating macaque and fishing cat can adapt somewhat readily to a life of swimming and foraging for crustaceans. Meanwhile, Zanzibar's red colobus monkey driven to coastal mangroves by deforestation can struggle to find the freshwater it needs, as Nowak reported in the American Journal of Primatology in 2008. Such a trend could result in local extinction of the red colobus nonetheless, she said.

Nowak concludes that swamp forests beg further exploration as places where endangered species such as lowland gorillas and flat-headed cats have preserved their numbers and where humans could potentially preserve them into the future.

###

The paper, "Mangrove and Peat Swamp Forests: Refuge Habitats for Primates and Felids," was published in the journal Folia Primatologica.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 28-Feb-2013
[ | E-mail | Share ]

Contact: Morgan Kelly
mgnkelly@princeton.edu
609-258-5729
Princeton University

Ecologists have evidence that some endangered primates and large cats faced with relentless human encroachment will seek sanctuary in the sultry thickets of mangrove and peat swamp forests. These harsh coastal biomes are characterized by thick vegetation particularly clusters of salt-loving mangrove trees and poor soil in the form of highly acidic peat, which is the waterlogged remains of partially decomposed leaves and wood. As such, swamp forests are among the few areas in many African and Asian countries that humans are relatively less interested in exploiting (though that is changing).

Yet conservationists have been slow to consider these tropical hideaways when keeping tabs on the distribution of threatened animals such as Sumatran orangutans and Javan leopards, according to a recent Princeton University study in the journal Folia Primatologica. To draw attention to peat and mangrove swamps as current and possibly future wildlife refuges, Katarzyna Nowak, a former postdoctoral researcher of ecology and evolutionary biology at Princeton, compiled a list of 60 primates and 20 felids (the large-cat family that includes tigers and leopards) known to divide their time between their natural forest habitats and some 47 swamp forests in Africa and Asia.

[Images can be seen at http://blogs.princeton.edu/research/2013/02/28/where-the-wild-things-go-folia-primatologica/. To obtain high-res images, contact Princeton science writer Morgan Kelly, (609) 258-5729, mgnkelly@princeton.edu]

Because swamp forests often lack food sources, fresh water and easy mobility, few mammals are exclusive to these areas, Nowak reported. Consequently, conservation groups have not intensely monitored the animals' swamp use.

But the presence of endangered cats and primates in swamp forests might be seriously overlooked, Nowak found. About 55 percent of Old World monkeys primates such as baboons and macaques that are native to Africa and Asia take to the swamps either regularly, seasonally or as needed. In 2008, the Wildlife Conservation Society reported that the inaccessible Lake Tl swamp forest in the Republic of the Congo was home to 125,000 lowland gorillas more than were thought to exist in the wild. Among big cats, the Bengal tiger, for instance, holds its sole ground in Bangladesh in the Sundarbans, the world's largest mangrove forest.

Life in the swamps can still be harsh for some animals. Species such as the crab-eating macaque and fishing cat can adapt somewhat readily to a life of swimming and foraging for crustaceans. Meanwhile, Zanzibar's red colobus monkey driven to coastal mangroves by deforestation can struggle to find the freshwater it needs, as Nowak reported in the American Journal of Primatology in 2008. Such a trend could result in local extinction of the red colobus nonetheless, she said.

Nowak concludes that swamp forests beg further exploration as places where endangered species such as lowland gorillas and flat-headed cats have preserved their numbers and where humans could potentially preserve them into the future.

###

The paper, "Mangrove and Peat Swamp Forests: Refuge Habitats for Primates and Felids," was published in the journal Folia Primatologica.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2013-02/pu-wtw022813.php

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Steve Carell On Brick In 'Anchorman 2': 'He Will Not Evolve. He Will Devolve' (VIDEO)

Steve Carell dropped by "The Tonight Show" to talk up the upcoming sequel to "Anchorman." While he didn't drop too many plot details, he did give an update on how much his character, Brick, has changed since the 2004 original film.

Jay Leno asked him how much his character has evolved in the past decade.

"He will not evolve. He will devolve," Carell said. "That was my hope with the movie, that it?s just going to be exactly the same."

Considering the worldwide success the first film enjoyed, this is probably the right idea. One change that will happen is that there will be even more funny faces, including Kristen Wiig as Brick's wife.

Director Adam McKay said he wants tons of funny people in the film, even if they only get a single line. He also is working in musical numbers to make "Anchorman: The Legend Continues" a truly memorable experience. The film is currently sheduled to open on December 20, 2013.

Watch "The Tonight Show with Jay Leno" every weeknight at 11:35 p.m. EST on NBC.

TV Replay scours the vast television landscape to find the most interesting, amusing, and, on a good day, amazing moments, and delivers them right to your browser.

Related on HuffPost:

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Source: http://www.huffingtonpost.com/2013/03/01/steve-carell-anchorman-2-brick-video_n_2787194.html

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